Spravato Depression Treatment FAQs

Depression Treatment Albany, NY

Depression is a mood disorder that affects millions of people. There are various methods for depression treatment, and Spravato is one of them. Spravato is a prescribed nasal spray that is taken with an antidepressant, and it is a treatment option for those with treatment-resistant depression and those with major depression accompanied by suicidal thoughts.

Frequently asked questions

Spravato is a relatively new depression treatment. As a result, many people have questions about it.

Who should take Spravato?

A doctor generally does not prescribe Spravato for initial treatment. It is recommended for two reasons. One is when someone has tried other treatment methods and has not gotten the results they want. This is called treatment-resistant depression.

Spravato is also prescribed for those with major depressive disorder with suicidal ideation. Because traditional antidepressants often take a few months to kick in, patients with MDSI may notice results quicker from Spravato.

What chemical is Spravato made with?

It is made with esketamine, which has been used for different medical purposes for years. Esketamine works differently than oral antidepressants.

How does it work?

Esketamine targets specific receptors in the brain. It increases the neurotransmitter glutamate, which helps combat common depression symptoms. Esketamine also assists the brain in forming new connections, which helps support long-term results.

What should one expect during depression treatment with Spravato?

Unlike oral antidepressants, which a patient can take at home on his or her own, Spravato must be taken in a clinical setting. There are potential side effects that a patient may experience for the first two hours after administering it, so a trained medical professional observes the patient during this time.

The patient self-administers the nasal spray and does three doses, each spaced five minutes apart. Once the time has passed and the potential side effects subside, the patient is free to go home.

During the first month, the patient will have two treatment sessions a week. During the second month, there is one treatment a week. Treatment sessions are then every two weeks or as needed.

How long until one notices results?

Spravato brings quick results. A patient usually notices symptom relief within hours of a depression treatment session. The results last for longer durations after subsequent sessions.

Are there any side effects from taking Spravato?

There are potential short-term side effects, which is why someone observes the patient during each treatment session. Side effects tend to be more intense during the initial treatment sessions and then lessen in later sessions. Common effects include:

  • Hallucinations or feelings of disconnect from reality
  • Headache
  • Feeling intoxicated
  • Nausea
  • Increase in blood pressure

Spravato is also a controlled substance, and it can lead to psychological or physical dependence if not used properly.


Depression can be challenging to treat, and it also takes antidepressants some time to get results, which is why there are various options. Spravato is a depression treatment that may be recommended when other treatments have failed or when someone feels suicidal and needs a faster remedy. 

Get more information here: https://albany.evolvepsychiatry.com or call Evolve Psychiatry at (518) 675-3097

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